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In genetics, the word hybrid can mean several things. In general, hybrid refers to the combination of two different things (eg. genes) to create something new.

The two most common meanings of hybrid are:

- an organism with two different alleles (versions of a gene) for a specific trait (eg. Bb, Tt). This means the organism is heterozygous for that gene.

- the offspring of two genetically distinct organisms (this would also be called a heterozygote).

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