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It depends on the type of chemical reaction. A reduction-oxidation reaction (redox reaction) involves the transfer of electrons, thus electrons are involved, for example
2Mg(s) + O2(g) > 2MgO(s)

However, reactions involving acids or bases involve the movement of protons (acids are proton donors, bases are proton acceptors) for example:

HCl(aq) + H2O(l) > Cl-(aq) + H3O+(aq)

Furthermore, there are nuclear reactions which can involve almost any particle. Therefore, the type of reaction determines the particle or type of particle involved.

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