Can genes fixed with gene therapy be transferred to offspring?

Answer 1

I do not personally work in that field but have studied it for a long time. This can be done, it was mainly tested on goats. Their offspring were deformed or perfectly fine. Same as when they did this to try to clone pets. The turn out the same, die right away or are deformed. My answer is Yes, both when you add it after their born or to their mother before they were born.

Answer 2

Gene therapy does not alter the germline cells (sperm and egg cells), so the corrected genes cannot be passed on to offspring. Any genetic modifications done in gene therapy would only affect the individual receiving the therapy and would not be heritable.