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Mint doesn't actually cool your mouth down. What happens is that the minty chemicals stimulate certain receptors in you mouth to send signals saying "hey it's cold in here". The culprit is a protein called the transient receptor potential cation channel subfamily M member 8 (TRPM8), which is expressed in sensory neurons. TRPM8 is an ion channel, a type of protein that regulates the movement of ions across the membranes of cells. Just like only certain keys can open a lock on a door, only certain stimulants can open the ion channel and access the cell. TRPM8 opens in the presence of cold temperatures and allows Na+ and Ca2+ ions to enter the cell. This changes the electrical charge within the neuron and the information being sent from the neuron to the central nervous system, eventually leading to the perception of cold.

Even after the mint is gone, a little bit of the minty chemical will remain and the sensory neurons will stay sensitized. Drinking anything cold or even taking in a big breath of cool air will cause the neurons to fire again, and the double whammy of the cool temperature and the menthol will make your mouth seem extra cold. Even a hot drink will seem weirdly cool and refreshing.

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8y ago

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