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no agonist affinity can be found from IC50 values where as antagonist affinity can be determined using EC50

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15y ago

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What is difference between inverse agonist and antagonist?

Hi friends before going to discuss about inverse agonist and antagonist i would like to introduce two terms namely AFFINITY & EFFICACY. affinity is the ability of a molecule to bind to the receptor and Efficacy is the ability to produce pharmacological response. Inverse agonist and antagonist both have affinity but differs in Efficacy aspect. Efficacy of inverse agonist is less than zero and efficacy of antagonist was zoro. Regards Jagadeesh Induri


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