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Prokaryotes are older, more basic in function and shape, do not contain a true nucleus or any membrane-bound organelles, unicellular (for the most part - some bacteria have multicellular stages in their life), and consist of bacteria and archae (old bacteria).

Eukaryotes can be uni- or multi-cellular, have a nucleus and membrane-bound organelles, are generally more complex in shape and function, much larger than prokaryotes and evolved later in history.

These are just some basic comparisons.

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