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Depletion of serum haptoglobin typically indicates hemolysis, the breakdown of red blood cells. In this condition, haptoglobin binds to free hemoglobin released from lysed erythrocytes, leading to a decrease in its serum levels. This can be associated with various clinical conditions, such as autoimmune hemolytic anemia, infections, or certain hemoglobinopathies. Monitoring haptoglobin levels can help in diagnosing and managing these conditions.

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5mo ago

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How is haptoglobin measured in rate nephelometry?

serum is mixed with a substance that will bind to haptoglobin. The amount of bound haptoglobin is measured using a rate nephelometer, which measures the amount of light scattered by the bound haptoglobin


What color tube for haptoglobin?

The haptoglobin test is typically collected in a red-top tube, which does not contain any additives. Alternatively, it can also be collected in a serum separator tube (SST).


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How are haptoglobin levels affected?

Haptoglobin levels can be affected by factors such as inflammation, infection, liver disease, and certain conditions like hemolytic anemia. In response to these conditions, haptoglobin levels may decrease as it is used up to bind free hemoglobin in the blood. Conversely, haptoglobin levels may increase in response to some inflammatory conditions.


What occurs in anemia?

so many red cells are destroyed that most of the available haptoglobin is needed to bind the released hemoglobin. The more severe the hemolysis, the less haptoglobin remains in the blood.


What occurs in hemolytic anemia?

so many red cells are destroyed that most of the available haptoglobin is needed to bind the released hemoglobin. The more severe the hemolysis, the less haptoglobin remains in the blood.


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