It decreases not just because of gravity. The pressure decreases because there is less air above you. As you increase your altitude, just like if you were coming up from deep under the water, there will be less fluid on top of you pushing down, so the pressure will decrease.
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Gary, Indiana, is approximately 600 feet (about 183 meters) above sea level. Its elevation can vary slightly in different areas of the city, but this figure provides a general reference for its height relative to sea level.
DefinitionFerritin is a protein found inside cells that stores iron so your body can use it later. A ferritin test indirectly measures the amount of iron in your blood.The amount of ferritin in your blood (serum ferritin level) is directly related to the amount of iron stored in your body.Alternative NamesSerum ferritin levelHow the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.How to prepare for the testYour doctor may tell you to stop taking any drugs that may affect the test results.How the test will feelWhen the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedThis test measures the amount of iron in the body. Iron is important for red blood cell production.Additional conditions under which the test may be performed:Anemia of chronic diseaseNormal ValuesMale: 12-300 ng/mLFemale: 12-150 ng/mLNote: ng/ml = nanograms per milliliterThe lower the ferritin level, even within the "normal" range, the more likely it is that the patient does not have enough iron.Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What abnormal results meanAny inflammatory disorder can raise the ferritin level.Higher-than-normal ferritin levels may be due to:Alcoholic liver diseaseFrequent transfusion of packed red blood cellsHemochromatosisLower-than-normal levels may be due to:Heavy menstrual bleedingIntestinal conditions that cause poor absorption of ironIron deficiency anemiaLong-term digestive tract bleedingWhat the risks areVeins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.Other risks associated with having blood drawn are slight but may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)ReferencesMcPherson RA and Pincus MR. Henry's Clinical Diagnosis and Management by Laboratory Methods. 21st ed. Philadelphia, Pa: WB Saunders; 2007:78.Hoffman R, Benz Jr. EJ, Shattil SJ, et al., eds. Hematology: Basic Principles and Practice. 4th ed. Philadelphia, Pa: Churchill Livingston; 2005:482.
DefinitionAmmonium ion test measures the amount of ammonium ions in a blood sample.Alternative NamesNH4+ test; Ammonia nitrogen levelHow the test is performedBlood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.How to prepare for the testFast for 8 - 12 hours. The health care provider may advise you to withhold drugs that may affect test results.Drugs that can interfere with the test include thiazide or loop diuretics, barbiturates, acetazolamide, neomycin, and oral kanamycin. Consult the health care provider before this test if you are taking any of these medications.How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedThis test may be performed when a condition that may cause toxic accumulation of ammonia is present or suspected. It is most commonly used to diagnose and monitor hepatic encephalopathy, a severe liver disease.Ammonia (NH4+) is produced by cells throughout the body, especially the intestines, liver, and kidneys. Most of the ammonia produced in the body is used by the liver in the production of urea. Urea is also a waste product but is much less toxic than ammonia.Ammonia is especially toxic to the brain and can cause confusion, lethargy, and sometimes coma.Normal ValuesThe normal range is 15 - 45 micrograms per deciliter (mcg/dL).Note: Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.What abnormal results meanConditions that can increase ammonia levels include:Liver failureSevere congestive heart failureErythroblastosis fetalisGastrointestinal (GI) bleeding - usually in the upper GI tractGenetic diseases of the urea cycleLeukemiaPericarditisReye syndromeCertain drugsWhat the risks areThere is very little risk involved with having your blood taken. Veins and arteries vary in size from one patient to another and from one side of the body to the other. Taking blood from some people may be more difficult than from others.Other risks associated with having blood drawn are slight but may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Patients with liver disease may have clotting problems. After the venipuncture, pressure should be applied to the puncture site for several minutes to ensure that bleeding has stopped.ReferencesBerk PD, Korenblat KM. Approach to the patient with jaundice or abnormal liver test results. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 150.
DefinitionSerum TBG level is a blood test to measure the level of a protein that moves thyroid hormone throughout your body. The protein is called thyroxine binding globulin (TBG).Alternative NamesSerum thyroxine binding globulin; TBG levelHow the test is performedBlood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.The sample is then taken to the laboratory where it is examined using special tests such as electrophoresis or radioimmunoassay.How to prepare for the testCertain drugs and medicines can affect test results. Your doctor may tell you to temporarily stop taking a certain medicine before the test. Never stop taking any medicine without first talking to your doctor.The following drugs can increase TBG levels:Estrogens, found in birth control pills and estrogen replacement therapyHeroinMethadonePhenothiazinesThe following drugs can decrease TBG levels:Depakote or depakene (also called valproic acid)Dilantin (also called phenytoin)High doses of salicylates, including aspirinMale hormones, including androgens and testosteronePrednisoneCertain medical conditions may also affect TBG levels. For example, TBG results may be increased in people with acute intermittent porphyria, HIV, or severe liver disease. They may be reduced in people with kidney failure or liver disease.How the test will feelWhen the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.Why the test is performedThis test may be done to diagnose problems with your thyroid, including thyroid disorders such as hypothyroidism.Normal ValuesIf electrophoresis is used, normal values may range from 10 mg/100 mL - 24 mg/100 mL.If radioimmunoassay is used, then a normal range is 1.3 - 2.0 mg/100 mL.Normal value ranges may vary slightly among different laboratories. Talk to your doctor about the meaning of your specific test results.The examples above show the common measurements for results for these tests. Some laboratories use different measurements or may test different specimens.What abnormal results meanIncreased TBG levels may be due to:Acute intermittent porphyriaHypothyroidismLiver diseasePregnancy (TBG levels are normally increased during pregnancy.)Note: TBG levels are normally high in newborns.Decreased TBG levels may be due to:AcuteillnessAcromegalyHyperthyroidismMalnutritionNephrotic syndromeStress from surgeryWhat the risks areVeins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.Other risks associated with having blood drawn are slight but may include:Excessive bleedingFainting or feeling light-headedHematoma (blood accumulating under the skin)Infection (a slight risk any time the skin is broken)Reviewed ByReview Date: 05/10/2010Frank A. Greco, MD, PhD, Director, Biophysical Laboratory, The Lahey Clinic, Burlington, MA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
DefinitionNewborn jaundice is a condition marked by high levels of bilirubin in the blood. The increased bilirubin cause the infant's skin and whites of the eyes (sclera) to look yellow.Alternative NamesJaundice of the newborn; Neonatal hyperbilirubinemiaCauses, incidence, and risk factorsBilirubin is a yellow pigment that's created in the body during the normal recycling of old red blood cells. The liver processes bilirubin in the blood so that it can be removed from the body in the stool.Before birth, the placenta -- the organ that nourishes the developing baby -- removes the bilirubin from the infant so that it can be processed by the mother's liver. Immediately after birth, the baby's own liver begins to take over the job, but this can take time. Therefore, bilirubin levels in an infant are normally a little higher after birth.High levels of bilirubin in the body can cause the skin to look yellow. This is called jaundice. Jaundice is present to some degree in most newborns. Such "physiological jaundice" usually appears between day 2 and 3, peaks between days 2 and 4, and clears by 2 weeks. Physiological jaundice usually causes no problems.Breast milk jaundice is another common, usually non-harmful form of newborn jaundice. Breast milk may contain a substance that increases reuse of bilirubin in the intestines. Such jaundice appears in some healthy, breastfed babies after day 7 of life, and usually peaks during weeks 2 and 3. It may last at low levels for a month or more.Breastfeeding jaundice is a type of exaggerated physiological jaundice seen in breastfed babies in the first week, especially in those that are not nursing often enough. Breastfeeding jaundice is different than breast milk jaundice, which occurs later and is caused by the milk itself.Sometimes jaundice can be a sign of a serious underlying problem. Higher levels of bilirubin can be due to:An event or condition that increases the number of red blood cells that needs to be processedAnything that interferes with the body's ability to process and remove bilirubinThe following increase the number of red blood cells that need to be processed:Abnormal blood cell shapes Congenital spherocytic anemiaElliptocytosisBlood type incompatibilities ABO incompatibility (Mother has type O blood, baby does not)Rh incompatibility (Mother is Rh negative, baby is not)Cephalohematoma or other birth injuryGlucose-6-phosphate dehydrogenase deficiencyHigh levels of red blood cells (polycythemia) More common in small for gestational age babiesMore common in some twinsInfectionPrematurityPyruvate kinase deficiencyTransfusionsThe following interfere with the body's ability to process and remove bilirubin:Alpha-1 antitrypsin deficiencyBiliary atresiaCertain medicationsCongenital cytomegalovirus (CMV) infectionCongenital herpesCongenital hypothyroidismCongenital rubellaCongenital syphilisCongenital toxoplasmosisCrigler-Najjar syndromeCystic fibrosisGaucher's diseaseGilbert syndromeHypoxiaInfections (such as sepsis)Lucey-Driscol syndromeNeonatal hepatitisNiemann-Pick diseasePrematurityIn otherwise healthy babies born at 35 weeks gestation or greater, those most likely to eventually develop signs of newborn jaundice are those who have:A brother or sister who needed phototherapy for jaundiceA high bilirubin level for their age, even if they are not yet jaundicedBeen exclusively breastfeed, especially if weight is excessiveBlood group incompatibility or other known red blood cell diseaseCephalohematoma or significant bruisingEast Asian ancestryJaundice in the first 24 hours of lifeSymptomsThe main symptom is a yellow color of the skin. The yellow color is best seen right after gently pressing a finger onto the skin. The color sometimes begins on the face and then moves down to the chest, belly area, legs, and soles of the feet.Sometimes, infants with significant jaundice have extreme tiredness and poor feeding.Signs and testsAll newborns should be examined for jaundice at least every 8 to 12 hours for the first day of life.Any infant who appears jaundiced in the first 24 hours should have bilirubin levels measured immediately. This can be done with a skin or blood test.Babies should be assigned a risk for later developing jaundice before they leave the hospital. Babies are classified as low risk, low intermediate risk, high intermediate risk, or high risk. Many hospitals do this by routinely checking total bilirubin levels on all babies at about 24 hours of age.Further testing varies on the infant's specific situation and test results. For example, the possible cause of the jaundice should be sought for babies who require treatment or whose total bilirubin levels are rising more rapidly than expected.Tests that will likely be done include:Complete blood countCoomb's testMeasurement of levels of specific types of bilirubinReticulocyte countThe level of albumin in the baby's blood may also be checked. Low albumin levels may increase the risk of damage from excessive jaundice.TreatmentTreatment is usually not necessary. Keep the baby well-hydrated with breast milk or formula. Frequent feedings encourage frequent bowel movements, which helps remove bilirubin through the stools. (Bilirubin is what gives stool a brown color).Sometimes special blue lights are used on infants whose levels are very high. This is called phototherapy. These lights work by helping to break down bilirubin in the skin. The infant is placed naked under artificial light in a protected isolette to maintain constant temperature. The eyes are protected from the light. The American Academy of Pediatrics recommends that breastfeeding be continued through phototherapy, if possible.In the most severe cases of jaundice, an exchange transfusion is required. In this procedure, the baby's blood is replaced with fresh blood. Treating severely jaundiced babies with intravenous immunoglobulin may also be very effective at reducing bilirubin levels.Expectations (prognosis)Usually newborn jaundice is not harmful. For most babies, jaundice usually resolves without treatment within 1 to 2 weeks. However, if significant jaundice is untreated, very high levels of bilirubin can damage the brain. For babies who require treatment, the treatment is usually quite effective.ComplicationsRare, but serious, complications from high bilirubin levels include:Cerebral palsyDeafnessKernicterus -- brain damage from very high bilirubin levelsCalling your health care providerAll babies should be seen by a health care provider in the first 5 days of life to check for jaundice.Those who spend less than 24 hours in a hospital should be seen by age 72 hours.Infants sent home between 24 and 48 hours should be seen again by age 96 hours.Infants sent home between 48 and 72 hours should be seen again by age 120 hours.Jaundice is an emergency if the baby has a fever, has become listless, or is not feeding well. Jaundice may be dangerous in high-risk newborns.Jaundice is generally NOT dangerous in term, otherwise healthy newborns. Call the infant's health care provider if jaundice is severe (the skin is bright yellow), if jaundice continues to increase after the newborn visit, lasts longer than 2 weeks, or if other symptoms develop. Also call the doctor if the feet, particularly the soles, are yellow.PreventionIn newborns, some degree of jaundice is normal and probably not preventable. The risk of significant jaundice can often be reduced by feeding babies at least 8 to 12 times a day for the first several days and by carefully identifying infants at highest risk.All pregnant women should be tested for blood type and unusual antibodies. If the mother is Rh negative, follow-up testing on the infant's cord is recommended. This may also be done if the mother blood type is O+, but it not necessarily required if careful monitoring takes place.Careful monitoring of all babies during the first 5 days of life can prevent most complications of jaundice. Ideally, this includes:Considering a baby's risk for jaundiceChecking bilirubin level in the first day or soScheduling at least one follow-up visit the first week of life for babies sent home from the hospital in 72 hoursReferencesAmerican Academy of Pediatrics (AAP). Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics. 2004 Jul;114(1):297-316.Mercier CE, Barry SE, Paul K, et al. Improving Newborn Preventive Services at the Birth Hospitalization: A Collaborative, Hospital-Based Quality-Improvement Project. Pediatrics. 2007 Sep;120(3):481-488.Moerschel SK, Cianciaruso LB, Tracy LR. A practical approach to neonatal jaundice. American Family Physician. 2008 May;77(9).
DefinitionJaundice is a condition that causes the skin and parts of the eyes to turn a yellow color.Breast milkjaundice is long-term jaundice in an otherwise healthy, breast-fed baby. It develops after the first week of life and continues up to the sixth week of life.Alternative NamesHyperbilirubinemia - breast-feedingCauses, incidence, and risk factorsBilirubin is a yellow pigment that is created as the body gets rid of old red blood cells. The liver helps break down bilirubin so that it can be removed from the body in the stool.If jaundice occurs or persists past the first week of life in an otherwise healthy and thriving breast-fed infant, the condition may be called "breast milk jaundice." It is probably caused by factors in the breast milk, which block certain proteins in the liver that break down bilirubin.Breast milk jaundice tends to run in families. It occurs equally often in males and females and affects approximately 0.5% to 2.4% of all newborns.SymptomsYour child's skin and whites of the eyes (sclera) will look yellow.Signs and testsLaboratory tests that may be done include:Bilirubin level (total and direct)Complete blood countBlood smear to look at blood cellsReticulocyte count to look at slightly immature red blood cellsBlood typingIn some cases, a blood test to check for glucose-6-phosphate dehydrogenase (G6PD) may be done. G6PD is a protein that helps red blood cells work properly.TreatmentTreatment will depend on:The baby's bilirubin levelHow fast it has been going outWhether your baby was born earlyHow old your baby is nowOften, the bilirubin level is relatively low (less than 20 mg/dL). Sometimes no specific treatment is needed other than close follow-up.More frequent nursing (up to 12 times a day) will increase the baby's fluid levels and can cause the bilirubin level to drop. Ask your doctor before giving your newborn extra formula.To help break down the bilirubin, your child may be placed under bright lights (phototherapy). If the bilirubin level is not too high or not rising quickly, you can do phototherapy at home.You can use either a fiberoptic blanket that has tiny bright lights in it, or a bed that shines light up from the mattress. A nurse will come to your home to teach you how to use the blanket or bed, and to check on your child.You must keep the light therapy on your child's skin and feed your child every 2 to 3 hours (10 to 12 times a day). Feeding prevents dehydration and helps bilirubin leave the body.Therapy will continue until your baby's bilirubin level is low enough to be safe.If the bilirubin level is more than 20 mg/dL, different treatment options are available. The mother can stop nursing for 24 to 48 hours, which will cause the bilirubin level to rapidly drop. During that time she can express the milk or pump her breasts (to maintain her comfort and the flow of milk) while feeding the baby formula. In most cases, when nursing is restarted the bilirubin will not return to previous levels.The baby may need to stay in the hospital to receive treatment if the bilirubin level is greater than 20 mg/dL. Along with phototheapy, fluids given through a vein can help increase the baby's fluid level and help lower bilirubin levels.Expectations (prognosis)Full recovery is expected with appropriate monitoring and treatment.ComplicationsWith appropriate treatment, there are usually no complications. However, failure to receive timely and proper medical care can have severe consequences, since high bilirubin levels can be harmful to the baby's brain and other organs.Calling your health care providerCall your health care provider immediately if you are breast feeding your baby and the baby's skin or eyes become yellow (jaundiced).PreventionBreast milk jaundice cannot be prevented. When the condition occurs, it is very important to recognize the baby's yellow color as early as possible and have bilirubin levels checked right away to make sure that there are no other liver problems.Breast feeding jaundice can be limited by making sure your baby is getting enough breast milk. Give your baby unlimited time at each breast, and feed approximately 10 to 12 times per day starting the first day of life. Get help from a lactation consultant or your doctor as soon as possible if you have any difficulty.ReferencesMoerschel SK, Cianciaruso LB, Tracy LR. A practical approach to neonatal jaundice. Am Fam Physician. 2008;77:1255-1262.
Day Labor- 15GDestroy all of the pinatas in the "It's All Greek to Me" levelThis is done in level 1 "It's All Greek to Me," when you go to talk to Mort. There are a total of 6 pinatas. Look around the frat house, they are impossible to miss.Employee of the Month- 20GKill VernonThis is done in level 7 "Santa's Sweatshop". When you enter Santa's Sweatshop, you will notice a picture of Vernon on the wall. Vernon will appear from around the corner and come after you. Simply kill him and the achievement will popPervert- 10GHang around the room with Quagmire in a baby costume for 30 secondsThis is done in level 5 "No Cheese, Please". Once you fix and lower down the walkway using the crane lever walk across, and go down the hallway. Go into the third room to the left. You will see Quagmire on the bed. Simply stand there of 30 seconds and the achievement will popWrecking Ball- 20GSmash your opponent into something 20 times in the "Chicken Fight!" levelThis is done in level 9 "Chicken Fight!". This is pretty hard not to get and also it does not have to be done all at one time. It can also be obtain by replaying the level. There are four parts to this fight. The first three are inside the airport with a numerous of breakable objects, last fight scene will be take place outside with a few breakable objectsIf playing in co-op, the second controller will be the chicken, making it a little easier to smash him into somethingBunch of Chumps- 15GSurvive 15 waves in Multiverse MadnessSee "Cartoon Apocalypse" achievementCartoon Apocalypse- 30GSurvive 30 waves in Multiverse MadnessMultiverse Madness is similar to a Firefight mode or a Horde mode. This will roughly take you about 2 hours to complete. This is easier done in co-op. After the first 10 rounds all enemies will get a x1.5 attack damage and health upgrade & from round 20 - 30 all enemies will get a x2.0 attack damage and health upgradeUgly Tastes Terrible- 5GPlay poorly during the final showdownThis is done on level 10 "No Place Like Home". On the third phase of the final fight, simply let yourself die by getting hit by some of the cars being thrown at you or by the smaller Bertram enemiesBird is the Word- 10GTaunt 5 times in a row with PeterNote: Peter is only available through multiplayer or during challenges.To get this simply start up a local multiplayer match and choose Peter. When the game starts press down on the d-pad 5 times in a row. This will make Peter do the "Bird is the Word" danceBig Dipper- 40GEarn 21 stars in Challenge modeTo earn 21 stars you will have to earn 3 stars on all 7 challenges. Recommend to play these challenges in co-op (can be done solo), but in co-op if a player gets down there will be a 3 second spawn wait, which is better than having only 1 life playing in soloLittle Dipper- 15GEarn 10 stars in Challenge modeSee "Big Dipper" achievementTeabag a D-Bag- 5GTaunt a dead opponent with Quagmire in MultiplayerTo be able to unlock Quagmire as a playable character you will first need to find all 15 photos in the level "It's All Greek To Me." Then you will be able to purchase him for $3000.Once you have Quagmire unlocked. Go into a local multiplayer match, and kill the opponent. Go over to them and press down on the d-pad to tauntRefer to "Obsessed" to view the location of the photosGrease Can't Save You Now- 20GWin a Capture the "Greased-Up Deaf Guy" matchSee "Lockdown" achievementJustified- 40GKill 500 enemies using BrianThis should come naturally during your game play. Make sure to kill all the enemies you come across.If you are missing a number of kills or want to grind this out replay level 7 "Santa's Sweatshop". Enter the sweatshop, flip the switch to make the elevator active, ride the elevator up, and on the second assembly line there will be an infinite spawning of suicide elf's. You can also do "Stewie-nator" hereStewie-nator- 40GKill 500 enemies using StewieSee "Justified" achievementBestest Infiltrator- 20GWin an Infiltration mapInfiltration is the basic object multiplayer mode. Simply start multiplayer game, with standard settings. Have player one go and do all the objectives until the score limit has been meetMort Will Now Lend You Credit- 30GBuy everything available in the StoreYou will need to buy everything that is available in the store from the Main Menu: Characters, Costumes, Upgrades, Attributes, etc... You are looking at roughly $100,000 to $150,000 to purchase everything from the store.If you need a few bucks or need to get money fairly quickly. You can replay level 5 "No Cheese, Please," as you get roughly $10,000. You get $120 for each Secret Service Agent head shot.There is no Cake- 100GUnlock all other AchievementsThis will be your last and final achievement. Unlocks after all other 47 achievements have been unlockedSome have reported this as a glitched achievement, and have had problems unlocking this achievement. It is not 100% confirmed on how this will glitch on you, but people say it has to do with the multiplayerHead Shot- 5GYou got your first head shotSee "One Shot Kills" achievementOne Shot Kills- 5GYou've killed an enemy with one shotThis will come with natural progression, along with "Head Shot". All the weapons are pretty much a successful one shot to the head kills. Focus on aiming for the head to have a better chance of getting a one shot kill.Multi-Kill- 15GYou successfully performed a multi-kill with a melee weaponThis can be obtained early in the game. On level 1 "It's All Greek To Me," you will come to a part where you will have to go over a gate to get to the frat house. Do not go over the gate just yet, instead, you will notice three girls running towards you. Pick Stewie, since his melee weapon is a golf club and has good range. Swing at the girls by pressing B rapidlyMulti-kill with a grenade- 15GYou successfully performed a multi-kill with a grenadeThis can be obtained early in the game. On level 1 "It's All Greek To Me."You will come to a part where you will have to go over a gate to get to the frat house. Do not go over the gate just yet, instead you will notice three girls running towards you. Pick Brian, press RB to throw the molotov/grenade when the girls are cluttered togetherFirst Kill- 10GYou completed your first kill of a member of the opposing team in MultiplayerGo into a multiplayer mode and start up and game mode. Once the game starts score a kill on a opposing playerRoadhouse- 15GYou've meleed 3 members of the opposing team in MultiplayerGo into multiplayer mode and start up and game mode. Once the game starts find either 3 or the same opposing player 3 times and press B to land a melee attackIts All Greek to Me- 20GYou completed the "It's All Greek To Me" levelThis will come at the end of level 1 after you brining back the speakers for Mort's frat partySomething's Amish- 20GYou completed the "Something's Amish" levelThis will come at the end of level 2 after you defeat the robot boss. To defeat it, shoot the targets in its eyes and then shoot the enemy that pops out from the top the robots head. Rinse and repeat until the robot is defeatedHandicapable- 20GYou completed the "Handicapable" levelThis will come at the end of level 3. After you defeat Crippletron. Use the three cannons in the area to shoot Crippletron. Crippletron will summon a few cripple enemies, which are annoying. So defeat them before mounting the cannons to shoot CrippletronPussy Whipped- 20GYou completed the "Pussy Whipped" levelThis will come at the end of level 4 after destroying a few tanks you will need to defeat an Evil Stewie and then Mayor WestNo Cheese, Please- 20GYou completed the "No Cheese, Please" levelThis will come at the end of level 5 after you assassinate the cheeseburgerLong John Peter- 20GYou completed the "Long John Peter" levelThis will come at the end of level 6 after you defeat Long John Peter. Use Brain with hes sniper and shoot Long John Peter in the headSanta's Sweatshop- 20GYou completed the "Santa's Sweatshop" levelThis will come at the end of level 7 after you kill all the reindeers on Santa's Christmas sledChickens in Space- 20GYou completed the "Chickens In Space" levelThis will come at the end of level 8 after you defeat the giant chicken. Use Brian with his sniper and shoot the chicken in the head. Once the chicken stops moving, run over and pull the lever located under the chicken to fry it. Do this a few more times until the chicken is defeatedChicken Fight!- 20GYou completed the "Chicken Fight!" levelThis will come at the end of level 9. Win all four stages of the fight with Peter to unlock the achievementNo Place Like Home- 50GYou completed the "No Place Like Home" levelThis will come at the end of level 10 after you defeat Bertram and his T-Rex. There are three phases to this boss fight.Tips:Phase 1 - T-Rex Lasers: Run into the parking garage as Stewie. This will keep you safe from the T-Rexs laser attacks and you will also be able to control the small Bertram enemies. As Stewie switch to your satchels and throw them at the T-Rex from the second floor of the parking garage. This will cause the most damage against the T-Rex. Also use the magma gun to defeat the small Bertram enemies. When you start to run low on satchels and ammo, keep killing the small enemies until they drop an ammo. Buying two health packs is recommended to stay alive. This first phase of this fight is the hardest. If you die, the T-Rex will return to full heath.Phase 2 - T-Rex Rockets: This phase is a lot much easier. As Brian use either the sniper rifle or the rail gun to shoot the rockets on the side of the T-Rex. The rockets are heat seeking. I suggest staying close to the start of the second area as there will also be some small enemies running around. They aren't much of a threat this time around, but it helps to kill them when they are close by. If you run low on ammo you can run into the garage to the left and use the ammo cache.Phase 3 - T-Rex Car Toss: Another simple phase. The T-Rex will now pick up cars with its mouth. Once the T-Rex has a car in its mouth shoot it so it blows up. Rinse and repeat until you defeat the T-Rex. You can use either Stewie or Brian. I used Brian with the shotgun.Obsessed- 50GYou've completed all secondary objectivesSecondary Objectives are the games collectibles, hidden throughout 9 of the 10 levels (Chicken Fight! is the only level with no secondary objectives)NOTE: The Secondary Objectives will not register for the achievement unless you finish the level. DO NOT QUIT before that.Also, if you replay a level that you are missing a collectible in, the counter will restart and you will have to collect all the collectables for that level again.We Be Clubbing- 15GYou defeated 10 enemies with a melee weaponWill come with natural progression. Use B to melee enemiesLockdown- 20GYou've shut out the other team from scoring in Capture the Greased-Up Deaf GuyGo into multiplayer and choose capture the Greased-Up Deaf Guy and have your second controller signed in. Now, when the the match starts wait a few seconds until he spawns. Quickly find him and melee, B him to knock him out since he will dodge if you shoot at him. Pick him up and run back to your base to get a point. Continue to repeat this processes until you get a flawless winPenny Pincher- 40GYou've successfully collected $50,000This is really straight forward. You do not have to have $50,000 at one time, this is accumulative. So that means you can buy as many upgrades to make your playthrough easier. There are two ways in getting money, first one is to find stacks of money laying around and the second is by scoring kills on enemies. The amount you get for killing enemies varies, but will double always when you score a headshotMr. Unpopular- 5GYou selected Meg as a character for a Multiplayer MatchGo into multiplayer and start up any game mode and have player one choose MegThe Cleaner- 30GYou got a 10 kill streak in DeathmatchGo into multiplayer mode with a second controller and start up a deathmatch. Kill the second player 10-times-in-a-rowTeabaggin'- 15GYou've successfully completed a taunt 25 timesTo taunt press down on the d-pad , and keep pressing it until the achievement unlocks.To kill 2 birds with 1 stone, Pick Peter to get "Bird is the Word" achievementIEDead- 15GThis will come with natural progression. To use a grenade/explosives press RB. If you do not have this after you have completed the game or want to grind this out replay level 7 "Santa's Sweatshop." Enter the sweatshop, flip the switch to make the elevator active, ride the elevator up, and on the second assembly line there will be an infinite spawning of suicide elf'sHelp From My Friends- 15GYou used the collectible special inventory items 25 times in Story ModeWill come with natural progression.Special inventory are small power ups scatter through on all levels. Once you have a special inventory, hold Y to summon your inventory wheel and use LB or RB to cycle through your inventory. When you select the special inventory, press LB to use it. Repeat this 24 more timesBoom Head Shot- 15GYou've killed 75 enemies with head shotsThis will come with natural progression. You can start this as early as level 1. When it comes to dealing with the enemies, aim for their heads. You will know when you get a headshot because you will receive double the money you would for just get a normal bodyshot kill. If you are still missing this after you have completed the game or want to grind this out replay level 7 "Santa's Sweatshop". Enter the sweatshop, flip the switch to make the elevator active, ride the elevator up, and on the second assembly line there will be an infinite spawning of suicide elf'sBiploar- 10GYou've switched between Brian and Stewie 10 timesTo switch between Brain and Stewie, press down on the d-pad. Do this 10 times either in a row or during your playthroughShut Up Meg- 5GYou killed Meg during a Multiplayer MatchGo into multiplayer. Start up any game mode, player one can pick whoever and then have player two choose Meg. Once the match starts, find and kill Meg for your achievementScorched Earth- 10GYou burned the Amish pot fieldsThis is done on level 2 "Something's Amish." Later in the level you will go down a path and see a circular area with pot plants around it. Use Stewie's flamthrower gun or the magma gun to burn down the pot field. You will have to walk through the pot field to be able to complete the levelHow Do I Jump?- 5GYou killed yourself with a grenade or satchel chargePress RB to drop a grenade or a satchel charge directly in front of yourself, and get blown up by itKings of Quahog- 20GYou have won a Deathmatch mode (free-for-all or as a team)Go into multiplayer. Set up a Deathmatch mode with default settings, and also have your second controller plugged in. Once the match starts, keep killing the second controller until the time runs out or the score limit is reached