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Mitochondria are fundamental for energy production (in the form of ATP), so without mitochondria the quantity of "energy" that can be produced will be substantially reduced. In mammals, both red blood cells and white muscle fibres are in the situation that they lack mitochondria. So, In terms of their cellular respiration, they can only proceed as far as Glycolysis which takes places the cell's cytoplasm. Cells with mitochondria can proceed to the TCA Cycle (or Krebs' cycle) stage of respiration, which takes place in the matrix of the mitochondria, and then to the final stage of respiration - The Electron Transport System which takes place in the cristae of the mitochondria.

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