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Yes, both white blood cells and red blood cells do. RBCs have no nucleus but still must sustain an active metabolism to maintain the flexibility and integrity of the red cell membrane as well as to preserve hemoglobin in its functional form to ensure adequate oxygen delivery. WBCs are a part of the human immune system and they create a number of enzymes that help fight disease. Sometimes, these enzymes damage tissues in inflammatory diseases such as chronic obstructive pulmonary disease, cancer and heart disease.

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