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The genome is the entire DNA list on how an organism is to be made; it is a recipe and a set of instructions on how to make 'things' or components in the organism for it to live and survive. By following these instructions, the body can put together bits to make proteins. These bits are amino acids. Proteins once made, have a 'destiny' and go to their destined location to carry out their fated function.

Cells are made of a bunch of different proteins. At the center of each cell is a control center known as the nucleus which contains these instructions for survival. So yes, it needs the same DNA in all cells. HOWEVER, the expression of the DNA is different in different cells with different functions and components. The DNA is set of instructions but it can be selectively picked apart for coding to produce certain types of proteins. And that is why bone cells differ greatly from muscle cells, though they still have the same DNA.

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