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In general, metals become more reactive as you move from right to left along a row in the periodic chart. They also are generally more reactive as you move down a column.

Non-metals however are a different story. Non-metals tend to be more reactive as you move from left to right along a row or as you move up a column. Disregarding, of course, the last column of the periodic chart (VIII) as the noble gases are non-reactive (inert).

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