Does the erythrocyte become haemolysed if the solution is still clear and how to explain this situation?

Answer 1

The erythrocyte can become haemolysed even if the solution(serum/plasma) is still clear. Visible check on haemolysed serum/plasma is not reliable as this is subject to the inspector. A haemolysed sample is defined when the concentration of the HGB in the serum/plasma is more than 100 mg/dl and not suitable for further laboratory testing. Therefore, erythrocyte in a clear serum/plasma may still be haemolysed, just that the level of haemolysed may be less than 100 mg/dl, and still suitable for laboratory testing.

Answer 2

Yes, an erythrocyte can become hemolyzed even if the solution remains clear. Hemolysis can occur due to factors like osmotic imbalances, mechanical stress, or the presence of certain chemicals. Clear solution indicates that the hemoglobin released from the lysed erythrocytes is well dissolved in the surrounding fluid.