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In hemoglobin, 4 subunits associate by noncovalent interactions.

In collagen, three chains associate in a triple helix by noncovalent interactions and the triplet helices are covalently cross linked by a series of reactions including lysine residues being converted to hydroxylysine by the action of ascorbic acid (vitamin C). The loss of this reaction is the cause of connective tissue breakdown in scurvy.

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