How are noble gases difference from other families?

Answer 1

Noble gases have completely filled orbitals / energy levels. They generally have 8 valence electrons (helium has only 2) and have stable electronic configuration. Hence they are chemically inert and generally do not form compounds under normal conditions.

Answer 2

Noble gases are inert and generally do not react with other elements, while other families of elements are more reactive and form compounds readily. Noble gases have a full valence shell of electrons, making them stable and unreactive. In contrast, other families of elements have incomplete valence shells and tend to gain, lose, or share electrons to achieve a stable electron configuration.