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The purpose of staining is generally to make the cells as a whole or some feature of the cells readily observable under the microscope. Most unstained cells, be they individual cells or in tissue sections, under a light microscope are rather transparent and hazy looking. Few features can be discerned. Staining the tissue makes it possible to observe details, although which detail will depend on which stain. H&E (hematoxylin and eosin) is a common staining combination used for tissue sections. It renders nuclei purple-blue and most tissue an easily visible red-pink. Also common these days are antibody stains where antibodies are applied to a cell or tissue section that recognize a particular antigen (e.g. a particular protein type) and can therefore be used to identify any cell or cellular structure possessing that protein. There are a great number of stains, each with specific purposes, benefits, and limitations.

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