How do Integral membrane proteins function?

Answer 1

The location of their polar and non-polar amino acids.

I'll buy that. But there's more. the membranes are hydrophyllic (polar) on the outside and hydrophobic (non-polar) on the inside. Proteins that pass through the membrane are stabilized by the membrane, and also stabilize the membrane in return. Based on the sequence of the amino acids, there are polar / hydrophyllic parts of the protein and nonpolar / hydrophobic parts. They interact with the membrane like little magnets to hold everything in place...

Answer 2

Integral membrane proteins span the lipid bilayer of the cell membrane, allowing them to interact with molecules inside and outside the cell. They play key roles in cell signaling, transport of molecules across the membrane, and cell adhesion. Their hydrophobic regions anchor them in the lipid bilayer, while their hydrophilic regions interact with the aqueous environments inside and outside the cell.

Answer 3

the locations of their polar and non-polar amino acids

Answer 4

transport of hydrophilic molecules through the membrane.