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¡Physical effects of amphetamine can include hyperactivity, dilated pupils, vasoconstriction, blood shot eyes, flushing, restlessness, dry mouth, bruxism, headache tachycardia, bradycardia, tachypnea, hypertension, hypotension, fever, diaphoresis, diarrhea ,constipation, blurred vision, aphasia, dizziness, twitching, insomnia, numbness, palpitations, arrhythmias, tremors, dry and/or itchy skin, acne, pallor, convulsions, and with chronic and/or high doses, seizure, stroke, coma, heart attack and death can occur. There is also significant research which highlights the changes amphetamine produces in the dopaminergic system, even in clinical doses. One possible interpretation is that neurotoxic effects exist even with doses approved for medical use.

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