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By many methods, depending on the disinfectant, I'll tell you quickly about three very common ones.

Soap - consists of many amphillic molecules similar to that seen in detergent, which bind to lipids on one end and bind to water on the other end. Scrubbing with soap will cause these molecules to bind against the lipid membrane of bacteria and upon washing off with water will rip these membranes apart.

Alcohol - has a wide bactericidal range and this is due to the many ways alcohol interferes with cellular function. Fast evaporation results in cell dehydration. Its ability to dissolve in some non-polar medium results in lipid membrane disruption. Its ability to bind to polar groups as well as penetrate a lipid bilayer results in protein distruption.

Oxidizing agent - usually used on inanimate surfaces as it can easily damage living tissues. These agents work to oxidize (rip electrons away) from cell membranes and cause cell lysis and death.

Since all the above methods are a result of physical distruption, bacterial cannot become "immune" to such chemicals and hence these disinfecting techniques will likely continue to work against bacteria for centuries to come. There is an exception for bacterial spores which are similar to plant seeds, they are inanimate but can come to life when in the right conditions.

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