How do large particles enter the nucleus?

Answer 1

Endocytosis, particularly, phagocytosis because the amoeba surrounds the food particle and engulfs it. The food particle is then enclosed into a food vacuole inside the cell where it can be accessed when the cell needs food.

Answer 2

Large particles enter the nucleus through nuclear pore complexes which are large protein structures that control the movement of molecules in and out of the nucleus. These nuclear pore complexes allow specific proteins and RNAs to be transported into the nucleus through a process called nuclear import.