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The sound causes vibration of special structures in our ear. These structures, called stereocilia, are basically sort of "cell hair". When these hair move, a signal in the cells is produced. This signal is transmitted by nerves to brain. The existence of this signal in brain = "activation of brain cells".

How do our brain cells work when we talk? They just produce signals leading to nerves which control our vocal centers. The question is not specific enough.

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