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You have to hit them hard enough to rattle their brain inside their head.

Actually you must weigh the advantages with the disadvantages.
The advantages are, um, none.
These are some disadvantages.
In order to knock someone out you will have to hit them hard enough to break your hand and some fingers. The head and jaw is harder than your hand. This is not good. If you hit someone hard enough to knock them out, it can also kill them. This is also bad. If you hurt them or kill them they can sue you or have you arrested and then you will go to jail. This is not good. To inflict pain on someone is a last resort. If you ask how to knock someone out, this means that you have premeditated it. This is bad.

All in all you should not attempt it.

The plate and screws in my sons hand are proof that it is a bad idea.

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15y ago

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What is a gene that is knocked out called?

Degene


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