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chemical reactions involve collisions between molecules. most collisions don't have either the right orientation or enough energy for the reaction to proceed. the molecules just bounce off each other, unchanged. incidentally that is why reactions proceed faster as the temperature increases - high temperature means molecules are moving faster and are more likely to have the required energy to react.

enzymes are protein catalysts that force reactant molecules into the correct orientation and lower the required energy for a collision to produce a reaction.

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