Once Charlie becomes a genius after his surgery, his personality undergoes a significant transformation. He becomes more introspective and emotionally distant, often feeling isolated from those around him due to his heightened intelligence. While he gains the ability to think critically and understand complex concepts, he also grapples with feelings of alienation and a sense of superiority, which contrasts sharply with his earlier, more innocent and naïve self. This change ultimately leads to a profound sense of loneliness as he realizes the emotional and relational costs of his newfound intellect.