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The first ribosome is formed through a process called ribosome biogenesis, which occurs in the nucleolus of the cell. Ribosomal RNA (rRNA) is synthesized from ribosomal DNA (rDNA) and combined with ribosomal proteins imported from the cytoplasm. This assembly creates the small and large subunits of the ribosome, which are then transported to the cytoplasm where they combine to form a functional ribosome, essential for protein synthesis.

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