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The renal fraction refers to the proportion of cardiac output that is delivered to the kidneys, typically around 20-25%. Although the kidneys make up only about 0.5-1% of total body weight, they receive a significant amount of blood flow relative to their size. This high renal fraction is crucial for their functions in filtration, regulation of electrolytes, and waste removal, underscoring the kidneys' efficiency despite their relatively small size.

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