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Cold hardy plants acclimatize by shifting cellular contents and altering metabolic processes as temperatures drop. Water content is shifted out of cells so freezing crystallization is extracellular. Protective stress induced proteins that alter enzyme function in cold are expressed. Oxidative stress induced antioxidents are expressed.

Endodormancy genes exist to be up regulated for acclimation and deacclimation as the plant goes into winter dormancy and comes out of dormancy.

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