Cancellous bone, or spongy bone, has many open spaces and contains marrow. It is softer and weaker than compact bone.
Blood cells are made in the bone marrow, which is located in the center of bones such as the hip, spine, and ribs. Red blood cells, white blood cells, and platelets are produced in the bone marrow. Additionally, during fetal development, blood cells are also made in the liver.
the inside of the bone is called bone marrow. it is a soft, fatty, vascular tissue that fills most bone cavities and is the source of red blood cells and many white blood cells.
Yes, bone marrow is considered nutrient-dense and can be a healthy addition to one's diet. It is rich in vitamins, minerals, and fatty acids that support overall health, and it is particularly high in collagen, which is beneficial for joint health and skin elasticity. Pairing bone marrow with other nutrient-rich foods can enhance its health benefits.
Bone marrow contains hematopoietic stem cells that can differentiate into various types of blood cells, such as red blood cells, white blood cells, and platelets. These stem cells undergo a process of differentiation and maturation to produce the different types of blood cells needed for proper functioning of the immune system and oxygen transport in the body.
There are three types of bone marrow transplant procedure. One of the three is called an Autologous bone marrow transplant. With an Autologous bone marrow procedure, doctors take the persons own bone marrow and freeze it before chemo then reintroduce the marrow into red blood cells after chemo or radiation. The second type is Allogeneic. In an Allogeneic marrow procedure the marrow is taken from a matching marrow donor. The third type is called Umbilical cord blood transplant. With an umbilical cord blood transplant, there can be a wider variety of donor as the cells are still considered immature.
Bone marrow transplants are accompanied by serious and life-threatening risks. Furthermore, they are not always an absolute assurance of a cure for the underlying ailment; a disease may recur in the future.
For adults there are many different conditions treated with bone marrow transplants such as; Amyloidosis, Aplastic anemia,Leukemia and Lymphoma. Once a BMT even cured somebody with aids...
There are two types of bone marrow: red marrow(consisting mainly of hematopoietic) tissue and yellow marrow (consisting mainly of fat cells).Red Blood Cels, platelets, and most white blood cells arise in red marrow. Both types of bone marrow contain numerous blood vessels and capillaries.
Bone marrow transplants involve replacing damaged bone marrow with healthy bone marrow stem cells. This can be used to help many stem cell related illnesses, sometimes including cancer.
Cancellous bone, or spongy bone, has many open spaces and contains marrow. It is softer and weaker than compact bone.
DefinitionA bone marrow transplant delivers healthy bone marrow stem cells into the patient. It replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation.Alternative NamesTransplant - bone marrow; Stem cell transplant; Hematopoietic stem cell transplant; Reduced intensity, nonmyeloablative transplant; Mini transplant; Allogenic bone marrow transplant; Autologous bone marrow transplant; Umbilical cord blood transplantDescriptionBone marrow is the soft, fatty tissue inside your bones. Stem cells are immature cells in the bone marrow that give rise to all of your blood cells. Your blood is made of:Red blood cells (which carry oxygen to your tissues)White blood cells (which fight infection)Platelets (which help your blood clot)In a bone marrow transplant, you will receive healthy stem cells after your own bone marrow has been destroyed.There are three kinds of bone marrow transplants:Autologous bone marrow transplant. "Auto" means "self." Stem cells are taken from the patient before the patient gets chemotherapy or radiation treatment. When chemotherapy or radiation is done, the patient gets their stem cells back. This is called a "rescue" transplant. It allows the patient to receive high doses of chemotherapy and radiation.Allogeneic bone marrow transplant. "Allo" means "other." Stem cells come from another person, who is called a donor. Donor stem cells come from the donor's bone marrow or their blood. Most times, a donor must have the same genetic typing as the patient, so that their blood "matches" the patient's. Special blood tests will tell whether a possible donor is a good match for the patient. A patient's brothers and sisters have the highest chance of being a good match (25% chance for each full sibling), but sometimes parents and children of the patient and other relatives may be matches. Donors who are not related to the patient may be found through national bone marrow registries.Umbilical cord blood transplant. Stem cells are taken from an umbilical cord right after delivery of an infant. The stem cells are tested, typed, counted, and frozen until they are needed for a transplant. Umbilical cord blood requires less stringent matching because the stems cells are so immature.Many patients get high doses of chemotherapy, radiation, or both, before the bone marrow transplant. This is called ablative (or myeloablative) treatment. It kills any cancer cells that might remain, and it makes room in the bone marrow for the new stem cells to grow.Today, some patients are getting less chemotherapy and radiation before their transplant. This is called a reduced intensity (nonmyeloablative) or "mini" transplant.After the patient gets chemotherapy and radiation, a doctor will do the stem cell transplant. The patient gets the stem cells through a tube called a central venous catheter. The process is similar to receiving a blood transfusion. The cells go right into the bloodstream and find their own way to the bone marrow. Usually, no surgery is required.Donors may have minor surgery to collect their bone marrow and stem cells. For a bone marrow harvest, they will be unconscious and pain-free (under general anesthesia) while their bone marrow is removed from their hip bone. In many cases however, stem cells can be collected right from the blood. The donor will first receive injections for a few days.When receiving stem cells, a patient may have these symptoms:PainChillsFeverHivesChest painDrop in blood pressureShortness of breathNauseaFlushingHeadacheFunny taste in the mouthWhy the Procedure Is PerformedBone marrow or stem cell transplant may be recommended for:Certain cancers, such as leukemia, lymphoma, and multiple myelomaIllnesses where the bone marrow does not produce the right kind of or enough cells. Some of these are: Sickle cell anemiaAplastic anemiaThalassemiaCongenital neutropeniaSevere immunodeficiency syndromesRescue transplant to replace bone marrow, when treatment for cancer has destroyed a patient's bone marrowRisksAll bone marrow transplants have risks. The risk is higher or lower depending on many factors. Some of these factors are:What disease you haveWhat type of treatment (chemotherapy, radiation) you have before the bone marrow transplantHow old you areHow healthy you are when you have your transplantHow good a match your donor isWhat type of bone marrow transplant patient you are having (autologous, allogeneic, or umbilical cord blood)Complications you may have are:Infections: These may be very serious.Bleeding: This can happen in the lungs, the intestines, brain, and any other part of the body.AnemiaDiarrhea, nausea, and vomitingPainSevere mucositis (inflammation and soreness) in the mouth, throat, esophagus, and stomachDamage to the kidneys, liver, lungs, and heartCataractsEarly menopauseGraft failure, which means that the new cells do not settle into the body and start producing stem cellsGraft-versus-host disease: This is when your donor's cells attack your own body. In the first few months after the transplant, symptoms may be a skin rash, diarrhea, or abnormal liver tests. Later, symptoms may be dry eyes or mouth, tightness of the skin, scarring in the lungs, chronic diarrhea, and other problems.Children who get transplants may have delayed growth.Before the ProcedureYour health care provider will ask you about your health record and do a physical exam. You will also have many tests before your treatment begins.Your doctor or nurse should discuss the emotional stress of having a bone marrow transplant. You may want to meet with a mental health counselor talk. Talking with your family and children to help them understand and prepare is important.You will need to make plans for when you have the transplant. Items to consider are:Household choresCare of petsPayment of billsBank or financial statementsSchedules and care for your childrenInsurance coverageArranging medical leave from workAdvanced care directivesYou may need to find housing for yourself or your family near the hospital.Before the transplant, one or two catheters are inserted into larger blood vessels, usually in the neck, for you to receive treatments, fluids, and sometimes nutrition.After the ProcedureBone marrow transplant patients usually go to medical centers, or hospitals, that specialize in this treatment. Most times the patient will stay in a bone marrow transplant unit in the center to limit their chance of getting an infection.Some patients who get autologous or non-myeloablative allogeneic transplants do not have to stay in the hospital or medical center. They can get the transplant as an outpatient.Some patients may have part of their autologous or allogeneic transplant done as an outpatient.Most patients will be in the hospital for 4 to 6 weeks. During this time, you will be isolated and watched closely because of the increased risk of infection.While you are in the hospital, these things may happen:Close monitoring of your blood and vital signsYou may have to take antibiotics, antifungal medications, and antivrial medications to prevent or treat infection.You may need many blood transfusions.You may have to stay in a room where special things are done to prevent infection.You may get calories and proteins through an intravenous (IV) line until you can eat on your own, and until your diarrhea, nausea, or mouth sores have cleared up.You may have to take medicine to prevent graft-versus-host disease.Outlook (Prognosis)How well you do after transplant greatly depends on these things:What type of bone marrow transplant you hadHow well your donor's cells match yoursWhat type of cancer or illness you haveYour age and overall healthWhat type of chemotherapy or radiation therapy you had before your transplantWhat kind of complications happened after the transplantYour genetic make-upPossible results of a bone marrow transplant are complete cure of the illness being treated, a partial cure, or death. Death may be caused by complications of the bone marrow transplant or because the transplant did not work to treat the illness.If the transplant works, you can go back to most of your normal activities as soon as you feel well enough. Most times it takes up to 12 months to recover fully.ReferencesBishop MR, Pavletic SZ. Hematopoietic stem cell transplantation. In: Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, McKena WG, eds. Clinical Oncology. 4th ed. Philadelphia, Pa: Elsevier Churchill Livingstone; 2008:chap 32.Vose JM, Pavletic SZ. Hematopoietic stem cell transplantation. In: Goldman L, Ausiello D. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 184.
Giving a person bone marrow allows them to make more red blood cell or white blood cells. Bone marrow is the ingredients to making these products. The circulatory uses the bone marrow from a donor.
Marrow
a marrow
India has become a leading destination for bone marrow transplants due to its world-class medical facilities, experienced specialists, and cost-effective treatment options. The country has several top hospitals equipped with state-of-the-art technology and a strong track record in treating blood disorders like leukemia, lymphoma, thalassemia, and sickle cell disease. One of the foremost experts in this field is Dr. Gaurav Kharya, a renowned bone marrow transplant surgeon with over 20 years of experience. He specializes in complex procedures, including haploidentical transplants and pediatric bone marrow transplants. Dr. Kharya serves as the Clinical Lead at the Center for Bone Marrow Transplant and Cellular Therapy at Apollo Hospitals in New Delhi. His expertise in treating challenging cases, coupled with his contributions to cell and gene therapy research, has made him a preferred choice for patients from across the globe. Dr. Kharya’s approach focuses on personalized patient care, innovative treatment options like CAR T-cell therapy, and ensuring the best outcomes for his patients. He has successfully performed over 1000 transplants, and his success rate is among the highest in India. For anyone considering a bone marrow transplant in India, it’s crucial to choose a specialist with a proven track record. With his extensive experience and leadership in pediatric hematology and immunology, Dr. Gaurav Kharya is considered one of the best bone marrow transplant surgeons in India. If you’re exploring bone marrow transplant options in India, Dr. Kharya’s team can guide you through the entire process, from initial evaluation to post-transplant care. You can learn more or schedule a consultation through his official website:
Bone marrow contains two types of stem cells: hemopoietic (which can produce blood cells) and stromal (which can produce fat, cartilage and bone). But the number of cells depend on which bone it is. The total number of cells in our body cannot be counted accurately However the total number of cell in an average human being is about 10^13 to 10^14