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What is Terminal half life?
Terminal plasma half-life is the time required to divide the plasma concentration by two after reaching pseudo-equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half-life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limiting factor, the terminal half-life reflects rate and extent of absorption and not the elimination process (flip-flop pharmacokinetics). The terminal half-life is especially relevant to multiple dosing regimens, because it controls the degree of drug accumulation, concentration fluctuations and the time taken to reach equilibrium.
What is a suitable half-life?
Suitable half-life of a radioactive element or isotope depends upon its uses. For example, a digested, radioisotope such as Iodine 131 requires a short half life so as to be expelled from the body quickly, while Technetium 99m used in industry and machines requires a long half-life to reduce the regularity of replacement.
What is an isotope that the time it takes it to decay to half its original mass?
c.half-life
What is the half life of promethium?
Promethium 145 has a half life of 17.7 years. Promethium 146 has a half life of 5.53 years. Promethium 147 has a half life of o.22 years.
What regulation of steady life-maintaining conditions inside an organism?
Homeostasis
What is plasma decay?
Plasma decay refers to the time that it takes for the concentration in blood plasma of a substance to reach one-half of its steady-state value. This is also referred to as the plasma half-life.
How to calculate the steady state from the half-life of a substance?
To calculate the steady state from the half-life of a substance, you can use the formula: Steady state concentration Initial concentration x (1/2)(t/h), where t is the time elapsed and h is the half-life of the substance. This formula helps determine the amount of substance that remains in a system after reaching a stable equilibrium.
A drug with a half-life of 12 hours is administered by continuous intravenous infusion How long will it take for the drug to reach 90 percent of its final steady-state level and why?
40 hours :)
What is pharmaceutical half life?
Pharmaceutical half-life is the time it takes for half of a drug to be metabolized and eliminated from the body. It helps determine dosing frequency and how long a drug remains effective in the body.
What is the process for using a half-life steady state calculator to determine the equilibrium concentration of a substance over time?
To use a half-life steady state calculator to determine the equilibrium concentration of a substance over time, you need to input the initial concentration of the substance, the half-life of the substance, and the time period you are interested in. The calculator will then calculate the equilibrium concentration based on the given parameters.
Clinical significance of determination plasma half life of drug?
Plasma half life is the most important factor determining the dosage frequency. it also decides the time taken for the drug to reach steady state plasma concentration, which takes about 4-5 half lives to achieve. we can calculate how long the drug is going to stay in the body by knowing its half life as it is the time taken for the drug concentration to halve.
Does a star have a half life?
Not really, a half-life is applied to substances on a steady exponential decay. Stars have more dramatic life histories so the concept of a half-life is not really applicable.
How can I use a drug steady state calculator to determine the optimal dosage for a patient?
To determine the optimal dosage for a patient using a drug steady state calculator, you would input the drug's half-life, dosing interval, and desired steady state concentration. The calculator will then calculate the dosage needed to achieve and maintain the desired drug levels in the patient's system. This helps ensure the drug is effective and safe for the individual.
How long does the drug enbrel stay in your system?
According to ePocrates, etanercept (Enbrel) has a half-life of 102 hours, which is four and a quarter. Using the rule that 4-5 half-lives are required to reach steady-state, it'd take around 17-21 days for the drug to leave one's system. This is very approximate, however. Please discuss this with the physician who prescribed this medication.
The steady state so vital to life is possible because?
all reactions are equilibrium
What is the steady state or constant condition necessary for life and maintained by the body is called?
Homeostasis.
What is Terminal half life?
Terminal plasma half-life is the time required to divide the plasma concentration by two after reaching pseudo-equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half-life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limiting factor, the terminal half-life reflects rate and extent of absorption and not the elimination process (flip-flop pharmacokinetics). The terminal half-life is especially relevant to multiple dosing regimens, because it controls the degree of drug accumulation, concentration fluctuations and the time taken to reach equilibrium.
