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The removal of a nodule from the thymus, typically performed through a procedure called thymectomy, is generally considered safe, especially when conducted by an experienced surgical team. However, as with any surgery, there are risks, including bleeding, infection, and complications related to anesthesia. The safety and outcomes can also depend on the patient's overall health, the size and nature of the nodule, and the specific surgical approach used. Careful preoperative evaluation and postoperative monitoring can help minimize risks.

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