Stabilizing selection for an intermediate optimum is generally considered to deplete genetic variation in quantitative traits. However, conflicting results from various types of models have been obtained. While classical analyses assuming a large number of independent additive loci with individually small effects indicated that no genetic variation is preserved under stabilizing selection, several analyses of two-locus models showed the contrary. We perform a complete analysis of a generalization of Wright's two-locus quadratic-optimum model and investigate numerically the ability of quadratic stabilizing selection to maintain genetic variation in additive quantitative traits controlled by up to five loci. A statistical approach is employed by choosing randomly 4000 parameter sets (allelic effects, recombination rates, and strength of selection) for a given number of loci. For each parameter set we iterate the recursion equations that describe the dynamics of gamete frequencies starting from 20 randomly chosen initial conditions until an equilibrium is reached, record the quantities of interest, and calculate their corresponding mean values. As the number of loci increases from two to five, the fraction of the genome expected to be polymorphic declines surprisingly rapidly, and the loci that are polymorphic increasingly are those with small effects on the trait. As a result, the genetic variance expected to be maintained under stabilizing selection decreases very rapidly with increased number of loci. The equilibrium structure expected under stabilizing selection on an additive trait differs markedly from that expected under selection with no constraints on genotypic fitness values. The expected genetic variance, the expected polymorphic fraction of the genome, as well as other quantities of interest, are only weakly dependent on the selection intensity and the level of recombination.
Hardy and Weinberg wanted to answer the question of how genetic variation is maintained in a population over time. They developed the Hardy-Weinberg equilibrium principle, which describes the expected frequencies of alleles in a population that is not undergoing any evolutionary changes.
Yes, it is. If there is variation in a populations, and a sudden catastrophic event occurs, there is more of a chance that some of the individuals in the population will survive, and the population will not die out.
A bell shaped curve of phenotypic variation is a graphical representation of the distribution of a trait within a population. It shows that most individuals in the population have an average value for the trait, with fewer individuals on the extreme ends of the spectrum.
No, natural selection works on that genetic variation presented to it.
The main source of genetic variation is a large population with a large gene pool.
Hardy and Weinberg wanted to answer the question of how genetic variation is maintained in a population over time. They developed the Hardy-Weinberg equilibrium principle, which describes the expected frequencies of alleles in a population that is not undergoing any evolutionary changes.
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Span the full spectrum of a population's genetic variation. <apex> Reflects the genetic variation of a population...
Yes, it is. If there is variation in a populations, and a sudden catastrophic event occurs, there is more of a chance that some of the individuals in the population will survive, and the population will not die out.
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the enviroment.
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Variation within a population in which few or no intermediate phenotypes fall between the extremes.
A large population increases genetics variation. Mutation will also increase genetics variation.
A variation within the population. Height in humans is an example of this.
Small Population