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Bacteria initiate infection by making use of virulence factors which are;

1. pilli: These are small hairs that enable some pathogens to attach easily to cell surfaces, particularly mucous membranes. bacteria possessing pilli include Neisseria gonorrheae and some strains of Escherichia coli, Salmonella and Shigella species

2. Production of enzymes that help pathogens to spread: for example, hyaluronidase produced by Clostridium perfringes and some Streptococci and Staphylococci,helps organisms to spread through the body by breaking down the hyaluronic acid of connective tissue.

3. production of beta-lactamases: These penicillin-destroying enzymes are produced by many bacteria including some strains of Staphylococcus aureus and Neisseria gonorrhoeae.

4. Mechanisms that interfere with phagocytosis: Bacteria such as Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae, and Neisseria meningitidis secrete a capsule around their cell wall which helps to prevent opsonization and phagocytosis.

5. production of exotoxin: several gram positive and a few gram negative bacteria secrete powerful poisons called exotoxins that are capable of destroying or injuring host cells. They tend to be specific in their action, e.g. the exotoxin of Clostridium tetani is neurotoxin.

6. Release of endotoxin: The cell walls of Gram negative organisms contain endotoxin ( O antigen ). When endotoxin is released into the blood circulation, the resulting toxaemia may cause shock, rigor, chills.

7. Mechanisms that destroy or neutralize antibodies: For e.g., the destructive IgA protease of Pseudomonas aeruginosa.

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