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Most of the detailled work in molecular Biology (or cell biology) depends on knowledge of the structure or cells. Cells are the basic building blocks in all organisms, and without microscopes we would be unable to explain even the simplist biological processes, such as where DNA is stored and where DNA is translated. With the event of electron microscopes, we can now even see the thinnest of cell walls, giving us a greater example of how diffusion, facilitated diffusion and active uptake are used to transfer molecules across a cell wall, vital for living organisms! Basically, unlike in physics, most biology depends on what we observe. And with a microscope, we can see tiny things. And it looks really spiffy if you're trying to appear clever.

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Ribosomes were not identified until the 1950s primarily due to the limitations of microscopy techniques available before that time. Early cell biology relied on light microscopy, which could not resolve structures as small as ribosomes. The advent of electron microscopy allowed scientists to visualize these tiny organelles, leading to their discovery and understanding of their role in protein synthesis. Additionally, the molecular biology techniques developed in the mid-20th century facilitated the study of ribosomal RNA and its functions.


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