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Tay-Sachs disease is caused by a genetic mutation in the HEXA gene on (human) chromosome 15. It is is a rare autosomal recessive genetic disorder and not sex-linked.
Two Tay-Sachs alleles are required for an individual to exhibit symptoms of the disease.
It causes a progressive deterioration of nerve cells and of mental and physical abilities that begins around six months of age and usually results in death by the age of four.
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