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As cardboard is made of several different kinds of ingredients, it is a mixture. When talking about pure substance in a chemical sense, most of the times, we mean a substance with a consistant atomic or molecular formula. To put it more clearly, it means that there can only be one kind of atom or molecule in this substance, such as Gold having only one kind of atom - "Au" and methane having only one kind of molecule - "CH4". Putting different pure substances together makes mixtures. Like our life, things can get mixed up really quick. As it turns out, we rarely come across any pure substance in our daily life. The main ingredient in cardboard, i suppose (without more specific information), is cellulose, which is also the main ingredient of paper. As cellulose is basicly fibers, which is not adhesive, they need adhesives to stick together. So at least you have two different kinds of substances in there, which makes cardboard a mixture.

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