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Gonadotropin release is primarily regulated by negative feedback mechanisms. In both males and females, sex hormones (like testosterone and estrogen) inhibit the secretion of gonadotropin-releasing hormone (GnRH) from the hypothalamus and luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. However, during specific phases of the menstrual cycle, estrogen can induce a positive feedback loop leading to a surge in LH, which triggers ovulation. Overall, the predominant regulatory mechanism for gonadotropin is negative feedback.

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3w ago

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