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Yes.

If you define the entire organism as your "system" (i.e. you set the boundaries of the system to include everything this is part of the organism or contained within it ), you can measure thermodynamic properties and perform calculations on that system.

Thermodynamic systems are typically defined in terms of how (or if) they interact with their environment.

An "open system" is one where the defined volume exchanges both mass and energy with its environment

A "closed system" is one where the defined volume may exchange energy with its surrounding environment but the mass within the system remains constant.

An "isolated system" is one where neither mass nor energy cross the boundaries of the system.

Most likely you would define the thermodynamic system of the organism as an "open system". If you seal it off so that no mass can enter or leave the system it would probably die pretty soon.

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