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Muscle Movement

Cognitive functioning

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12y ago

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What type of excitatory neurotransmitter is secreted by motor neurons innervating skeletal muscle?

Acetylcholine is the excitatory neurotransmitter released by neurons innervating skeletal muscles. Acetylcholine release stimulates muscle contraction by acting at the nicotinic-acetylcholine receptor on the surface of the muscle cell.


One of the 2 major degenerative disorders of the brain associated with nerotransmitter?

Alzheimer's disease is one of the major degenerative disorders of the brain associated with neurotransmitter imbalances, particularly acetylcholine. The other major disorder is Parkinson's disease, which is characterized by a deficiency of dopamine. Both conditions result in significant neurological and cognitive impairments.


Movement of arms and legs what major neurotransmitter involved?

Skeletal muscles move via action potential that is conducted by axons to the neuromuscular junction and across the synaptic gaps of efferent motor neurons. The main neurotransmitter responsible for this job is acetylcholine.


Where is the location of acetylcholine?

Acetylcholine is a neurotransmitter found throughout the nervous system, acting in both the central and peripheral nervous systems. It is primarily released from nerve endings at synapses, where it acts as a chemical messenger to transmit signals between nerve cells.


Name the major neurotransmitter in the body and what it specifically?

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What Two major neurotransmitters are involved in regulating physiological responses to exercise?

Acetylcholine and norepinephrine.


Two major neurotransmitters of the autonomic nervous system?

You have acetylcholine liberated at ganglion in both sympathetic and parasympathetic nervous system. You have noradrenaline secreted at post ganglionic sympathetic nerve terminals. You have acetylcholine secreted at post ganglionic parasympathetic nerve terminals.


What undersupply of the major inhibitory neurotransmitter is linked to seizures?

GABA (Gamma-Aminobutyric Acid)


What is acethylcoline?

I assume you mean Acetylcholine. Acetylcholine (often abbreviated ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the somatic nervous system. It is also the neurotransmitter in all autonomic ganglia. Acetylcholine has functions both in the peripheral nervous system (PNS) and in the central nervous system (CNS) as a neuromodulator. In the PNS, acetylcholine activates muscles, and is a major neurotransmitter in the autonomic nervous system. In the CNS, acetylcholine and the associated neurons form a neurotransmitter system, the cholinergic system, which tends to cause excitatory actions. In the peripheral nervous system, acetylcholine activates muscles, and is a major neurotransmitter in the autonomic nervous system. . When acetylcholine binds to acetylcholine receptors on skeletal muscle fibers, it opens ligand gated sodium channels in the cell membrane. Sodium ions then enter the muscle cell, stimulating muscle contraction. Acetylcholine, while inducing contraction of skeletal muscles, instead induces decreased contraction in cardiac muscle fibers. This distinction is attributed to differences in receptor structure between skeletal and cardiac fibers. In the autonomic nervous system, acetylcholine is released in the following sites: * all pre- and post-ganglionic parasympathetic neurons * all preganglionic sympathetic neurons ** preganglionic sympathetic fibers to suprarenal medulla, the modified sympathetic ganglion; on stimulation by acetylcholine, the suprarenal medulla releases epinephrine and norepinephrine * some postganglionic sympathetic fibers ** sudomotor neurons to sweat glands. In the central nervous system, ACh has a variety of effects as a neuromodulator, e.g., for plasticity and excitability. Other effects are arousal and reward. == Acetylcholine and the associated neurons form a neurotransmitter system, the cholinergic system. It originates mainly in pontomesencephalotegmental complex, basal optic nucleus of Meynert and medial septal nucleus, and projects axons to vast areas of the brain: * The pontomesencephalotegmental complex acts mainly on M1 receptors in the brainstem . * Basal optic nucleus of Meynert acts mainly on M1 receptors in the neocortex. * Medial septal nucleus acts mainly on M1 receptors in the hippocampus and neocortex. == ACh is involved with synaptic plasticity, specifically in learning and short-term memory. Acetylcholine has been shown to enhance the amplitude of synaptic potentials following long-term potentiation in many regions, including the dentate gyrus, CA1, piriform cortex, and neocortex. This effect most likely occurs either through enhancing currents through NMDA receptors or indirectly by suppressing adaptation. The suppression of adaptation has been shown in brain slices of regions CA1, cingulate cortex, and piriform cortex, as well as in vivo in cat somatosensory and motor cortex by decreasing the conductance of voltage-dependent M currents and Ca2+-dependent K+ currents. == Acetylcholine also has other effects on excitability of neurons. Its presence causes a slow depolarization by blocking a tonically-active K+ current, which increases neuronal excitability. It appears to be a paradox, however, that ACh increases spiking activity in inhibitory interneurons while decreasing strength of synaptic transmission from those cells. This decrease in synaptic transmission also occurs selectively at some excitatory cells: For instance, it has an effect on intrinsic and associational fibers in layer Ib of piriform cortex, but has no effect on afferent fibers in layer Ia. Similar laminar selectivity has been shown in dentate gyrus and region CA1 of the hippocampus. One theory to explain this paradox interprets acetylcholine neuromodulation in the neocortex as modulating the estimate of expected uncertainty, acting counter to norepinephrine (NE) signals for unexpected uncertainty. Both would then decrease synaptic transition strength, but ACh would then be needed to counter the effects of NE in learning, a signal understood to be 'noisy'. This information along with diagrams and much more can be found at Wikipedia.com


What is the major way that muscles become fatigued?

interruption in the muscle's blood supply or lack of acetylcholine in motor neuron axons


What are the benefits of choline?

Choline is a biological molecule that is known to serve a wide variety of purposes. Its major purpose, however, is as part of acetylcholine, one of the body's major neurotransmitters.


A major drawback from behavioral based detection is the increased numbers of?

False positives