Hemagglutination?
Overview:H1N1, H1N2, and H3N2 are the only known Influenza A virus subtypes currently circulating among humans. All the subtypes listed in the question, i.e., H1N1, H1N2, H3N1 and H3N2 are the known subtypes of influenza A viruses that are endemic in pigs and create influenza in pigs, from which reassortants have formed new strains that can be infective to humans. H1N1 is the "swine flu" subtype of influenza, of which there are several different strains. This subtype is usually seen in humans and pigs. The better known reassortant H1N1 virus strain currently circulating is H1N1/09, the pandemic swine flu virus that caused the pandemic of 2009 and infected humans, pigs, birds, ferrets, dogs, and cats during the pandemic. There are several other less well known strains of the H1N1 subtype.H1N2 is a common flu in pigs in the Upper Midwest of the US. Until 2011, only one case had been known to occur in humans and that was in 2007 in Michigan. The second ever known case was found in an infant in December 2011 in Minnesota.H3N1 mostly only infects pigs.H3N2 is the subtype that produced a strain of flu that caused the Hong Kong Flu and another was the cause of the Fujian Flu, etc. In birds, humans, and pigs, there have been many new strains mutated and this subtype is becoming more prevalent in seasonal influenza.For background, the meanings of "H" and "N" in the nomenclature:Hemagglutinin: An important surface protein on the capsid (coat) of the influenza virus that is essential for the reproduction and the spread of the virus in the body in the lytic cycle of virus replication. This protein enables the virus to attach itself to a cell in the respiratory system or other mucous tissue and penetrate it to invade and use the host cell for reproduction. Referred to as the "H" in influenza viruses.Neuraminidase: An important surface structure protein of the influenza virus that is an essential enzyme for the spread of the virus throughout the respiratory tract. It enables the virus to escape the host cell and infect new cells. Referred to as the "N" in influenza viruses.See more about the lytic cycle and influenza virus nomenclature in the related questions below.Types of Influenza VirusesThere are three types of influenza viruses: Types A, B and C. Influenza A and B viruses cause seasonal outbreaks and epidemics of influenza virus infections each flu season. Type A causes all pandemics. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Influenza A viruses are divided into subtypes based on the configuration of the two proteins on the surface of the viruses: hemagglutinin (H) and neuraminidase (N). [Not all H1N1 viruses are the same; not all H5N1 viruses are the same.....etc] There are 16 different hemagglutinin subtypes and 9 different neuraminidase subtypes. Influenza A viruses can be further broken down into different strains.Influenza B viruses are not divided into subtypes. Influenza B viruses also can be further broken down into different strains.Influenza A (H1N1), A (H3N2), and influenza B strains are included in each year's influenza vaccine. Getting a flu vaccination can protect against influenza A and B viruses. The flu vaccine does not protect against influenza C viruses.More information including how influenza viruses change: Drift and ShiftInfluenza viruses are dynamic and are continuously mutating, reassorting, and evolving. Influenza viruses can change in two different ways: antigenic drift and antigenic shift. Influenza viruses are changing by antigenic drift all the time, but antigenic shift happens only occasionally. Influenza type A viruses undergo both kinds of changes; influenza type B viruses change only by the more gradual process of antigenic drift. Antigenic drift refers to small, gradual changes that occur through point mutations in the two genes that contain the genetic material to produce the main surface proteins, hemagglutinin, and neuraminidase. These point mutations occur unpredictably and result in minor changes to these surface proteins. Antigenic drift produces new virus strains that may not be recognized by antibodies produced after exposure to earlier influenza strains.This process works as follows: a person infected with a particular influenza virus strain develops antibodies against that strain. As newer virus strains appear, the antibodies against the older strains might not recognize the "newer" virus to inactivate it, and infection with a new strain can occur. This is one of the main reasons why people can become infected with influenza viruses more than one time and why global surveillance is critical in order to monitor the evolution of human influenza virus stains for selection of which strains should be included in the annual production of influenza vaccine.In most years, one or two of the three virus strains in the seasonal influenza vaccine are updated to keep up with the changes in the circulating influenza viruses. For this reason, people who want to be immunized against influenza need to be vaccinated every year.Antigenic shift refers to an abrupt, major change to produce a novel influenza A virus subtype in humans that had not been currently circulating among people (see more information below under Influenza Type A and Its Subtypes).Antigenic shift can occur either through direct animal (poultry)-to-human transmission or through mixing of human influenza A and animal influenza A virus genes to create a new human influenza A subtype virus through a process called genetic reassortment or reassortant. Antigenic shift results in a new human influenza A subtype.A global influenza pandemic (worldwide spread) may occur if three conditions are met:A new subtype of influenza A virus is introduced into the human population.The virus causes serious illness in humans.The virus can spread easily from person to person in a sustained manner.
The normal number of WBCs in the blood is 4,500-10,000 white blood cells per microliter (mcL).There are 3 functional classes of lymphocytes:1. T cells (cell-mediated immunity) attack foreign cells directly.2. B cells (humoral immunity) differentiate into plasma cells which synthesize antibodies.3. Natural killer (NK) cells detect and destroy abnormal tissue cells such as cancers.
the body will produce the anti D- antibodies which are going to attack the RH+ blood of the donor usually the first time is not a threat since the formed antibodies are IgM class which has a very low conc. the second time is very dangerous due to the formation of memory cells that are activated in the second blood transfusion leading to the production of IgG antibodies in very high conc. leading to the agglutination of the blood and severe anemia
If an Rh negative person is exposed to Rh positive blood, their immune system may produce antibodies against the Rh antigen. Upon subsequent exposure to Rh positive blood, these antibodies can attack and destroy the Rh positive red blood cells, leading to a condition called hemolytic disease of the newborn (HDN) in pregnant women or a transfusion reaction in non-pregnant individuals.
If anti-B antibodies (from someone who is blood type A or AB) are mixed with group B red cells, agglutination or clumping of red cells will occur due to a reaction between the antibodies and the B antigen on the red cells. This can lead to transfusion reactions if incompatible blood is transfused, causing harm to the recipient.
They should not get sick with that specific flu (but could with others).
For the 3-6 months that the vaccine would have provided an improved immunity against influenza, the unvaccinated horse will be more susceptible to contracting influenza than a vaccinated horse.
If you don't vaccinate your horse against Influenza, then he will be more at risk of contracting this highly contagious disease.
you would probably have antibodies against the microbes and would probably be able to counter the infection.
If antibodies are tested too soon after exposure to Hepatitis C then it can produce a false negative result because the body has not had enough time to produce antibodies against the virus. If this happens, retest after a couple of months.
Elderly people are more likely to have developed antibodies in their blood over time. When this happens, it is harder to match blood for them to receive and there is a much smaller donor pool for them, so blood that they could receive is not as readily available.
The concentration of the antibodies skyrockets
After immunization against measles, the body responds by producing antibodies specific to the measles virus. These antibodies help recognize and neutralize the virus if exposed in the future. Additionally, the immune system creates memory cells that remember the virus, allowing for a quicker and more effective response upon subsequent exposures. This adaptive immune response provides long-lasting protection against measles infection.
Overview:H1N1, H1N2, and H3N2 are the only known Influenza A virus subtypes currently circulating among humans. All the subtypes listed in the question, i.e., H1N1, H1N2, H3N1 and H3N2 are the known subtypes of influenza A viruses that are endemic in pigs and create influenza in pigs, from which reassortants have formed new strains that can be infective to humans. H1N1 is the "swine flu" subtype of influenza, of which there are several different strains. This subtype is usually seen in humans and pigs. The better known reassortant H1N1 virus strain currently circulating is H1N1/09, the pandemic swine flu virus that caused the pandemic of 2009 and infected humans, pigs, birds, ferrets, dogs, and cats during the pandemic. There are several other less well known strains of the H1N1 subtype.H1N2 is a common flu in pigs in the Upper Midwest of the US. Until 2011, only one case had been known to occur in humans and that was in 2007 in Michigan. The second ever known case was found in an infant in December 2011 in Minnesota.H3N1 mostly only infects pigs.H3N2 is the subtype that produced a strain of flu that caused the Hong Kong Flu and another was the cause of the Fujian Flu, etc. In birds, humans, and pigs, there have been many new strains mutated and this subtype is becoming more prevalent in seasonal influenza.For background, the meanings of "H" and "N" in the nomenclature:Hemagglutinin: An important surface protein on the capsid (coat) of the influenza virus that is essential for the reproduction and the spread of the virus in the body in the lytic cycle of virus replication. This protein enables the virus to attach itself to a cell in the respiratory system or other mucous tissue and penetrate it to invade and use the host cell for reproduction. Referred to as the "H" in influenza viruses.Neuraminidase: An important surface structure protein of the influenza virus that is an essential enzyme for the spread of the virus throughout the respiratory tract. It enables the virus to escape the host cell and infect new cells. Referred to as the "N" in influenza viruses.See more about the lytic cycle and influenza virus nomenclature in the related questions below.Types of Influenza VirusesThere are three types of influenza viruses: Types A, B and C. Influenza A and B viruses cause seasonal outbreaks and epidemics of influenza virus infections each flu season. Type A causes all pandemics. Influenza type C infections cause a mild respiratory illness and are not thought to cause epidemics. Influenza A viruses are divided into subtypes based on the configuration of the two proteins on the surface of the viruses: hemagglutinin (H) and neuraminidase (N). [Not all H1N1 viruses are the same; not all H5N1 viruses are the same.....etc] There are 16 different hemagglutinin subtypes and 9 different neuraminidase subtypes. Influenza A viruses can be further broken down into different strains.Influenza B viruses are not divided into subtypes. Influenza B viruses also can be further broken down into different strains.Influenza A (H1N1), A (H3N2), and influenza B strains are included in each year's influenza vaccine. Getting a flu vaccination can protect against influenza A and B viruses. The flu vaccine does not protect against influenza C viruses.More information including how influenza viruses change: Drift and ShiftInfluenza viruses are dynamic and are continuously mutating, reassorting, and evolving. Influenza viruses can change in two different ways: antigenic drift and antigenic shift. Influenza viruses are changing by antigenic drift all the time, but antigenic shift happens only occasionally. Influenza type A viruses undergo both kinds of changes; influenza type B viruses change only by the more gradual process of antigenic drift. Antigenic drift refers to small, gradual changes that occur through point mutations in the two genes that contain the genetic material to produce the main surface proteins, hemagglutinin, and neuraminidase. These point mutations occur unpredictably and result in minor changes to these surface proteins. Antigenic drift produces new virus strains that may not be recognized by antibodies produced after exposure to earlier influenza strains.This process works as follows: a person infected with a particular influenza virus strain develops antibodies against that strain. As newer virus strains appear, the antibodies against the older strains might not recognize the "newer" virus to inactivate it, and infection with a new strain can occur. This is one of the main reasons why people can become infected with influenza viruses more than one time and why global surveillance is critical in order to monitor the evolution of human influenza virus stains for selection of which strains should be included in the annual production of influenza vaccine.In most years, one or two of the three virus strains in the seasonal influenza vaccine are updated to keep up with the changes in the circulating influenza viruses. For this reason, people who want to be immunized against influenza need to be vaccinated every year.Antigenic shift refers to an abrupt, major change to produce a novel influenza A virus subtype in humans that had not been currently circulating among people (see more information below under Influenza Type A and Its Subtypes).Antigenic shift can occur either through direct animal (poultry)-to-human transmission or through mixing of human influenza A and animal influenza A virus genes to create a new human influenza A subtype virus through a process called genetic reassortment or reassortant. Antigenic shift results in a new human influenza A subtype.A global influenza pandemic (worldwide spread) may occur if three conditions are met:A new subtype of influenza A virus is introduced into the human population.The virus causes serious illness in humans.The virus can spread easily from person to person in a sustained manner.
It is probably anatomically possible, but you have something seriously wrong with you if that happens.
A mother may transfer some IgG antibodies passively through the placenta to the fetus.
They decrease in numbers but still stay at a high rate