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The Ventilator should be adjusted to OPTIMIZE volume, not maximize. You optimize volume using objective data such as Pressure/Volume loops to look for overdistention "duck-billing", and volumes should be set initially based on ideal body weight. According to ARDSnet protocol weight should be based on- Males- 50+2.3(height in inches-60) and females- 45.5+2.3(height in inches-60), initially giving 8ml/kg working down to 4-5ml/kg if necessary.

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