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Usually only cost. Equipment to make and apply ozone to match a target dose has a payback of 3 - 10 years, and doubling the ozone makes the payback centuries.

Ozone does not affect hardness, will not reduce BOD (only COD), and does not provide a long-term kill necessary for, say, a water distribution system. Ozone works well as *one* of the tools of water treatment, not the only tool.

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