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You'd have to define your conditions for "efficiency". While in general prokaryotes are simpler than eukaryotes, they obviously have their own advantages because both have become very successful over the course of evolution. Prokaryotes can be more efficient than eukaryotes in protein translation, for example, as the use of operons and polycistrons allows for efficiency.

But eukaryotic cells have a lot of other advantages. In terms of energy production, eukaryotic cells may contain several mitochondria to generate ATP much faster than a prokaryote could on its own. After all, according to the endosymbiosis theory, mitochondria and chloroplasts have their origins as individual prokaryotes themselves.

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