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The carboxyl group (-COOH) is not acetylated because it is already a fully functionalized group that contains both a carbonyl (C=O) and a hydroxyl (–OH) component. Acetylation typically involves the addition of an acetyl group (–COCH3) to nucleophilic sites, and the hydroxyl group in a carboxylic acid is not a suitable site for acetylation due to its strong acidity and reactivity. Additionally, acetylation would convert the carboxyl group into an ester, which alters its chemical properties and functionality.

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4w ago

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