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He is not paralyzed, he suffers from ALS (or, in American colloquialisms: Lou Gerig's Disease).

The computer system attached to his wheelchair is operated by Hawking via an infra-red 'blink switch' clipped onto his glasses. By scrunching his right cheek up, he is able to talk, compose speeches and research papers, browse the World Wide Web, and write e-mails. The system also uses radio transmission to provide control over doors in his home and office.

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