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Prions are proteins that can cause misfolding of other proteins in the brain, leading to neurodegenerative diseases like Creutzfeldt-Jakob disease in humans. Due to their ability to self-propagate and resist normal sterilization techniques, prions pose a significant risk of spreading through contaminated tissues or medical instruments. Transmissible spongiform encephalopathies caused by prions are currently incurable and fatal.

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Research on prion diseases such as Creutzfeldt-Jakob disease and mad cow disease focuses on understanding the mechanisms of prion protein misfolding and aggregation, developing diagnostic tools, identifying potential therapeutic targets, and exploring strategies for prevention and treatment. Studies also investigate the transmission of prion diseases between species and the potential risks related to food safety and public health.


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