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Ryanodine receptors (RyRs) are calcium release channels located primarily in the sarcoplasmic reticulum of muscle cells, including cardiac and skeletal muscle. Their primary function is to mediate the release of calcium ions into the cytoplasm in response to various signals, such as depolarization of the cell membrane. This calcium release is crucial for muscle contraction, as it initiates the interaction between actin and myosin filaments. Additionally, RyRs play a role in various signaling pathways and cellular processes beyond muscle contraction.

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An inhibitor of what could be used to block the release of calcium from the endoplasmic reticulum?

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