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Blood is filtered out of the glomerulus, a "knot" of porous capillaries, into the glomerular capsule. From there the filtrate passes though the proximal convoluted tubule, the loop of Henle, and the distal convoluted tubule where the substrate concentration of the filtrate is fine tuned. The distal convoluted tubule empties into a collecting duct but that is generally not considered part of the nephron itself.

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