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That would depend on what is ignited. If you are referring to events such as the accident in Chemobyl. Upon meltdown, the nuclear core which is partly composed of graphite burned releasing radioactive smoke. There must be many chemical combustion reactions of all sorts happening depending on what has caught on fire. The major concern is the radioactive debris from the core spewing into the environment. There would not be a large explosion such as a nuclear bomb because the uranium used in the core is not enriched enough to detonate.

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