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Anions such as chloride and bicarbonate play essential roles in maintaining electrolyte balance in the body and regulating acid-base balance in the blood. Different anions can impact the excretory system differently: for example, chloride is primarily excreted by the kidneys, while bicarbonate is involved in buffering acids in the blood and is regulated by the kidneys. Imbalances in anion levels can lead to conditions like metabolic acidosis or alkalosis, affecting kidney function and overall health.

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