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The only totipotent cells in humans are the zygote and the early blastomeres produced during the first few cell divisions after fertilization. Totipotent cells have the ability to differentiate into any cell type, including both embryonic and extraembryonic tissues, such as the placenta. This potential is lost as cells begin to specialize and form the different layers of the developing embryo. After the early blastocyst stage, cells become pluripotent, capable of forming nearly all cell types but not extraembryonic tissues.

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1w ago

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